Introduction of synthetic technology
1. Feature
There is accumulation of technology about the guanidinized reaction which used cyanamide and hydrazine as materials, and the synthetic reaction of the nitrogen compound on the basis of a guanidine derivative, and it is the synthetic field of our company made the most elated.
It has little article composition on a laboratory level, and the equipment for trust to 100Lー5,000L, and can respond to the wide range amount of manufactures flexibly from several mg unit to system manufacture.
It has abundant synthetic actual results about composition of the compound which has complicated structure, and a compound with many synthetic processes.


2. A synthetic actual result and the example of examination
　(1) Composition of an optical activity compound
　　　(i) Composition which held stereostructure using asymmetric raw material.
　　　(ii) Optical resolution using tartaric acid

　(2) Diazotization and its circumference technology
　　　(i) Composition of heterocyclic compound using reduction condensation of a diazo-compound
　　　(ii) Halogenation by the Sandmeyer reaction and the hydrazine derivative by reduction of a diazo-compound.
　　　(iii) Nitoroso reaction and redaction of nitroso compound
　　　(iv) Composition of a heterocyclic compound using nitrogen-nitrogen combination.

　(3) Composition of a heterocyclic compound and the arrangement of a functionalgroup.
　　　(i) Composition of pyrimidine and conversion of a functional group
　　　(ii) Composition of triazolopyrimidine and conversion of a functional group.

　(4) Reaction of carbon-carbon combination and the degradation reaction.
　　　(i) A Friedel-Crafts reaction and a Mannich reaction.
　　　(ii) Halogenation and a Friedel-Crafts reaction.
　　　(iii) A Vilsmeyer reaction and a condensation of carbonyl compound.
　　　(iv) The alkylation of an active-methylene compound.

　(5) Oxidation-reduction reaction
　　　(i) The reduction amination by sodium boron hydride.
　　　(ii) An oxidization cyclization with sulfur.

　(6) Composition of a fluorine compound
　　　(i) Composition which uses a fluorine compound as materials.

　(7) Composition which uses cyanamide and hydradine as materials
　　　(i) Composition using a cyanamide derivative and hydradine.